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2 OMIM references -
4 associated genes
6 signs/symptoms
PROTEIN INTERACTIONS: 1
1 OMIM reference -
1 associated gene
9 signs/symptoms
Idiopathic juvenile osteoporosis
Coats disease

DKK1 NDP
LRP5
WNT1
WNT3A


INTERACTOME
ASSOCIATIONS

(click on a score value to see the evidence)
LRP5
(0.63)
NDP



Citations in the biomedical literature:


Idiopathic juvenile osteoporosis
DKK1 LRP5 WNT1 WNT3A
Coats disease
NDP



Idiopathic juvenile osteoporosis
Coats disease

Synonym(s):
- IJO
- Juvenile osteoporosis

Synonym(s):
- Congenital retinal telangiectasia
- Leber miliary aneurysm

Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare genetic disease
Classification (Orphanet):
- Rare developmental defect during embryogenesis
- Rare eye disease
- Rare genetic disease

Classification (ICD10):
- Diseases of the musculoskeletal system and connective tissue -
Classification (ICD10):
- Diseases of the eye and adnexa -

Epidemiological data:
Class of prevalence: unknown
Average age onset: childhood
Average age of death: -
Type of inheritance: autosomal dominant
Epidemiological data:
Class of prevalence: unknown
Average age onset: childhood
Average age of death: normal
Type of inheritance: sporadic

External references:
2 OMIM references -
No MeSH references
External references:
1 OMIM reference -
1 MeSH reference: D058456

Idiopathic juvenile osteoporosis
Coats disease

Very frequent
- Bone pain
- Mutiple fractures / bone fragility
- Osteoporosis / osteopenia / demineralisation / osteomalacia / rickets

Frequent
- Abnormal gait
- Motor deficit / trouble

Occasional
- Kyphosis


Very frequent
- Retinal vascular anomalies / retinal telangiectasia
- Strabismus / squint

Frequent
- Glaucoma
- Macular dystrophy / absence / hypoplasia of the macula
- Retinal detachment

Occasional
- Aniridia / iris hypoplasia
- Anterior chamber anomaly
- Cataract / lens opacification
- Visual loss / blindness / amblyopia